Research
Highlights
High quality phase 1 and 2 clinical trials suggest that psilocybin is efficacious in reducing depression and anxiety, including in life-threatening conditions. The effect sizes of psilocybin treatment trials are large, though limited diversity of clinical trials participants limits generalizability. In all of these trials, psilocybin is administered in the context of counseling support in the weeks before and after dosing. The FDA has designated psilocybin a breakthrough therapy for treatment of depression, indicating that preliminary clinical evidence suggests it may represent a significant improvement over existing therapies. Initial research also suggests that psilocybin may be efficacious in reducing problematic alcohol and tobacco use. Across studies, psilocybin increases spiritual well-being which may mediate other observed benefits. Study participants also commonly rate their psilocybin experiences as highly meaningful.
Oregon Psilocybin Advisory Board Rapid Evidence Review and Recommendations, July 30, 2021
Mindfulness
Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation and Psilocybin in the Treatment of Depression. A Review.
(Kristin Heuschkel et al., 2020)
Psilocybin
Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up
(Gukasyan et al., 2022)
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up
(R. Carhart-Harris et al., 2017)
Life Coaching
Cognitive-behavioral, solution-focused life coaching: Enhancing goal striving, well-being, and hope
(L. S. Green et al., 2006)
Research By Topic
Meditation
Does mindfulness training help with anxiety and depression when combined with psychotherapy? (Research Summary)
Psilocybin
Is psilocybin safe and effective in treating anxiety and depression when combined with psychotherapy? (Research Summary)
Meditation + Psilocybin
Is there research indicating a synergy between psilocybin and meditation? (Research Summary)
Research Disclaimer
The research studies and articles linked on this page are provided for informational purposes only. They represent ongoing scientific investigations into the potential therapeutic uses of psilocybin and related interventions. While these studies indicate promising results for some individuals in certain contexts, it is important to note:
Psilocybin is not currently approved by the U.S. Food and Drug Administration (FDA) as a treatment for any medical condition.
The research presented here is preliminary and ongoing. More comprehensive studies are needed to fully understand the efficacy, safety, and long-term effects of psilocybin-assisted therapies.
Results from these studies may not be generalizable to all individuals or conditions. Outcomes can vary significantly based on individual circumstances, mindset, setting, and other factors.
The use of psilocybin outside of approved research contexts or regulated frameworks (such as Oregon's psilocybin services program) remains illegal in most jurisdictions.
Any consideration of psilocybin as a potential therapeutic tool should be made in consultation with qualified healthcare professionals and in compliance with all applicable laws and regulations.
We encourage readers to approach this information with a critical mind and to consult with licensed healthcare providers for personalized medical advice. The field of psychedelic research is rapidly evolving, and we are committed to staying informed about the latest developments and maintaining the highest standards of ethical practice.